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Author Topic: GABA - can it cross blood brain barrier?  (Read 1065 times)

cubicleclown

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GABA - can it cross blood brain barrier?
« on: October 17, 2015, 11:28:36 PM »

I've been doing some research on GABA, one thing I've seen reported many times on forums and even some studies is that it can not cross the blood brain barrier.  Having felt the positive effects of GABA on my brain many times, I couldn't understand this.  After a bit more searching, I found an easy to understand website that explains that it indeed can cross the BBB in some situations, according to newer studies.  The website goes on to explain that there are measurable brain changes following oral GABA administration indicative of the effects attributed to it, though how this works they could not explain, and seemed to allude that an explanation currently isn't known or well understood.   This website sums up GABA and its benefits really well, and also gives an introduction to the blood brain barrier, and I think it is worth sharing.

https://www.getoptimind.com/gaba-supplements-blood-brain-barrier/

Does anyone have further information as to how GABA works? 
« Last Edit: October 17, 2015, 11:55:49 PM by cubicleclown »
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cubicleclown

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Re: GABA - can it cross blood brain barrier?
« Reply #1 on: October 22, 2015, 06:39:38 PM »

I want to add 1 more thing that I read from some random poster on a random forum, so this is far from being a good source of information, but it might contribute to discussion at least.  This person pointed out that blood brain barriers vary in effectiveness from person to person and he made the claim that if you feel effects from gaba supplements, it might indicate that yours is leaky.

Is this plausible?
« Last Edit: October 22, 2015, 07:15:17 PM by cubicleclown »
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cubicleclown

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Re: GABA - can it cross blood brain barrier?
« Reply #2 on: October 27, 2015, 06:52:33 PM »

I have some unusual news to report on my gaba use, over the past few days I've noticed I wake up feeling more anxious and crazier than usual, and when I take gaba it goes away.  This happens multiple times a day, 4 or so hours after my dose of gaba.  I think it's giving me some withdrawal.  I'm not going to take any more.
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akosi

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Re: GABA - can it cross blood brain barrier?
« Reply #3 on: October 29, 2015, 01:27:33 PM »

GABA is indeed active in my experiences, and no I do not buy the whole leaky blood brain barrier thing.  One would be in a lot of trouble in their blood brain barrier was broken.  Feeling psychoactivity from GABA would be the least of their concerns.

The supplement is indeed active, why so is unknown, but perhaps it has something to do with modulation of GABA levels throughout the body.  Say GABA does not cross the BBB when taken itself, but when it is dosed it activates GABA receptors in the body, freeing up endogenous GABA stores which can may have an influence on the brain's GABA receptors.

The body also likes to break things apart, build them back again, metabolism is a funny thing, and whether or not GABA is being deconstructed then rebuilt, it probably does have physiological active metabolites that may have an influence on global GABA levels (or simply bypass the BBB and elicit an effect).

There are just two of my hypothesis regarding the subject, but it clarifies that there is much more to the body than most "informed" individuals think there is, and that the activity of a substance has many variables, and can not be simply logically reduced to something as basic as "does this substance cross the BBB"?

The very same people who claim GABA is inactive are text-book, or rather arm-chair pharmacologists.  People who read the experiments of others and claim to possess the in depth knowledge themselves, with little regard to anecdotal experiences, even if they are the very ones perceiving them.  "It doesn't take a weather man to know which way the wind blows..."

In regards to the w/d, I bet GABA is indeed habituating, as are most things that activate the receptor.  St. John's wort is an odd one and works through gene regulation and expression, and appears (both in studies and in my own personal experiences) to stimulate AND upregulate serotonin and GABA receptors, while down regulating dopamine and beta adrenergic receptors.  It may even be able to alleviate mild cases of schizophrenia and similar disorders, both short term and long term.  I know of an individual who experienced about a year of a form of stimulant induced psychosis, who was subsequently cured of his anxiety and paranoia, for good, after a month long St. John's wort regimen via tea.
« Last Edit: October 29, 2015, 01:53:11 PM by akosi »
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Ben Haller

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Re: GABA - can it cross blood brain barrier?
« Reply #4 on: September 08, 2017, 10:19:17 PM »

I am very similar to the individual you described. I'm having all types of mental symptoms, some very serious. I am new to this site but in need of assistance from a fellow human being, I would not wish the anxiety levels I experience, or any other symptoms, on anyone. Any advise would be greatly appreciated. Please respond to the urgent basis of this post.
  Many thanks again
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