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Author Topic: Pineal gland calcification and the role of fluoride on pineal physiology  (Read 1630 times)

akosi

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Consumption of fluorine, fluoride, sodium fluoride, calcium fluoride, and most arrangements of such that are found in our food, water, and medical supply are toxic and known to cause damage to an important brain organ known as the pineal gland.  The damages include but are not limited to decreased IQ and a faster onset of puberty in children.  Other less scientifically based claims include the theory that fluoride damages our ability to connect to the spiritual realms.  While this may sound somewhat hard to swallow, when one follows the clues, the footprints lead where one may not expect.  In this post I will provide the sources and the reasoning to verify and backup these claims, and am more than happy to defend them as well with scholarly resources.


First off we are faced with the claim that fluoride is toxic to humans.  This is non-arguable and is evident on all sides.  Here is a wiki page with sources for the skeptics: (https://en.wikipedia.org/wiki/Fluoride_toxicity).  Here we see that fluoride is confirmed toxic to: kidneys, bones, teeth, thyroid, and debated to be toxic to the brain, which we will discuss.

Next, let us examine how and why the brain might be affected by fluoride.

Jennifer Anne Luke wrote The Effect of Fluoride on the Physiology of the Pineal Gland in 1997, it is a 300 page long dissertation submitted to the School of Biological Sciences, University of Surrey, in fulfillment of the requirements for the Degree of Doctor of Philosophy.  You can read the paper here: (http://epubs.surrey.ac.uk/895/1/fulltext.pdf).


Abstract:

The purpose was to discover whether fluoride (F) accumulates in the pineal gland and thereby affects pineal physiology during early development. The [F] of 11 aged human pineals and corresponding muscle were determined using the F-electrode following HMDS/acid diffusion. The mean [F] of pineal gland was significantly higher (p < 0.001) than muscle: 296 + 257 vs 0.5 + 0.4 mg/kg respectively. Secondly, a controlled longitudinal experimental study was carried out to discover whether F affects the biosynthesis of melatonin, (MT), during pubertal development using the excretion rate of urinary 6-sulphatoxymelatonin, (aMT6s), as the index of pineal MT synthesis. Urine was collected at 3-hourly intervals over 48 hours from two groups of gerbils, (Meriones unguiculatus), low-F (LF) and high-F (HF) (12 f, 12 m/group): under LD: 12 12, from prepubescence to reproductive maturity (at 9-12 weeks) to adulthood, i.e., at 7, 9, 11 1/2 and 16 weeks. The HF pups received 2.3 ug F/g BW/day from birth until 24 days whereafter HF and LF groups received food containing 37 and 7 mg F/kg respectively and distilled water. Urinary aMT6s levels were measured by radioimmunoassay. The HF group excreted significantly less aMT6s than the LF group until the age of sexual maturation. At 11 1/2 weeks, the circadian profile of aMT6s by the HF males was significantly diminished but, by 16 weeks, was equivalent to the LF males. In conclusion, F inhibits pineal MT synthesis in gerbils up until the time of sexual maturation. Finally, F was associated with a significant acceleration of pubertal development in female gerbils using body weights, age of vaginal opening and accelerated development of the ventral gland. At 16 weeks, the mean testes weight of HF males was significantly less (p < 0.002) than that of the LF males. The results suggest that F is associated with low circulating levels of MT and this leads to an accelerated sexual maturation in female gerbils. The results strengthen the hypothesis that the pineal has a role in pubertal development.



Chapter 10 – Discussion

After half a century of the prophylactic use of fluorides in dentistry, we now know that fluoride readily accumulates in the human pineal gland. In fact, the aged pineal contains more fluoride than any other normal soft tissue. The concentration of fluoride in the pineal was significantly higher (p < 0.001) than in corresponding muscle, i.e., 296 ± 257 vs. 0.5± 0.4 mg/kg (wet weight) respectively. The low fluoride content found in muscle in the current study was in agreement with the low fluoride content in soft tissues – less than 1 mg F/kg (WHO, 1984). This indicates that the method used in the present study had been properly executed; that fluoride in the pineal gland was endogenous and had not been introduced to the cadavers since the time of death, e.g., via the preserving formalin fluid. However, the pineal gland is unique in that it can be classified as a soft or as a mineralizing tissue. In terms of mineralized tissue, the mean fluoride concentration in the pineal calcification was equivalent to that in severely fluorosed bone and more than four times higher than in corresponding bone ash, i.e., 8,900 ± 7,700 vs. 2,040 ± 1,100 mg/kg, respectively. The calcification in two of the 11 pineals analysed in this study contained extremely high levels of fluoride: 21,800 and 20,500 mg/kg.

There is increasing interest in the determination of essential and toxic elements in neurological tissues. Fluoride metabolism in CNS has not been systematically studied. It is generally agreed that the CNS is impervious to the effects of fluoride by virtue of the blood-brain barrier (Whitford et al, 1979). The human pineal is outside the blood-brain barrier. The significance of this is not clear but it may be that the pineal needs to ‘sample’ the circulating blood. The results from this study are important because the pineal gland is obviously a hitherto unrealized target for chronic fluoride-toxicity.

The pineal fluoride content varied considerably between subjects (14-875 mg/kg) although it was directly correlated to pineal calcium content: r = 0.73, p < 0.02. Large amounts of calcium have been demonstrated in the pineals from young children. Indeed, the prevalence of pineal calcification in young children is higher than one may have been led to believe from radiological evidence alone (Tapp and Huxley, 1971; Reyes, 1982). In addition to its high calcium content, the pineal contains intracellular colloids, a high magnesium content (Krstic, 1976; Michotte et al, 1977; Allen et al, 1981); and a very proftise blood supply. These are all factors encouraging the acquisition of fluoride by soft tissues (WHO, 1970). High levels of magnesium, manganese, zinc and copper have been demonstrated in pineals which appear ‘uncalcified’ (Michotte et al, 1977). Therefore, it is likely that the child’s pineal also accumulates fluoride although this needs verification. The deposition of fluoride within the child’s pineal must be a recent phenomenon. The plasma-fluoride levels in young children are normally very low and what little there is is rapidly sequestered by the growing skeleton. The extensive use of fluorides in dentistry has caused an unprecedented increase in plasma-fluoride levels in infants and young children.

Any adverse physiological effects of fluoride depend upon the concentration at various tissue sites. Can pinealocytes function normally in close proximity to high concentrations of fluoride? One would predict that a high local fluoride concentration would affect pinealocyte function in an analogous way that a high local fluoride concentration affects: i) bone cells, since histological changes have been observed in bone with 2,000 mg F/kg (Baud et al, 1978); ii) ameloblasts, since dental fluorosis develops following fluoride concentrations of 0.2 mg F/kg in the developing enamel organ (Bawden et al, 1992). The consequences are disturbances in the functions of bone and enamel, i.e., changes in structure (poorly mineralized bone and enamel). If the pineal accumulates fluoride at an earlier age than in previous decades, one would anticipate that a high local concentration of fluoride within the pineal would affect the functions of the pineal, i.e., the synthesis of hormonal products, specifically melatonin. The highest levels of pineal melatonin are produced during early childhood.

The controlled animal study carried out in this study produce compelling evidence that fluoride inhibits pineal melatonin output during pubertal development in the gerbil. The LF males and LF females excreted similar amounts of the melatonin metabolite, aMT6s, in urine from prepubescence (7 weeks), throughout puberty to young adulthood (16 weeks). For example, at 7 weeks, the LF males and LF females excreted 30.7 ± 7.9 and 26.8 ± 6.8 ng aMT6s/24-h, respectively; at 16 weeks, 31.6 ± 10.9 and 29.8 ± 8.2 ng aMT6s/24-h. There was no sex difference. These results agree with previous reports that the rates of urinary aMT6s excretion remain constant during human puberty with no sex difference (Young et al, 1988; Bojkowski and Arendt, 1990; Tetsuo et al, 1982).


Here are some more papers and a pictures of an extracted calcified pineal gland:

http://ehp.niehs.nih.gov/1104912/


http://revelationnow.net/wp-content/gallery/pineal_power/calc_pineal_500.jpg



That is quite a lot of mineral deposit!  Thankfully, not all of it is from fluoride.  These mineral deposits form naturally throughout life, and in fact are made of the same mineral compositions as teeth are, hydroxyapatite.  This is precisely why the pineal gland also accumulates fluoride.  You can read about the process of hydroxyapatite becoming fluorapatite here: http://carifree.com/patient/learn/protective-factors/fluoride.html

Now the problem is laid clear in front of us.  We are consuming something that is harmful, on a daily basis.  This substance has proven to be harmful to multiple organs, is considered a toxic waste by the EPA, interacts with hormones, and lowers IQ.  Whether or not the pineal gland is the actual seat of the soul is of no concern here.  We are looking at a poison that is being distributed to the masses.  I will let you all speculate on the reasons, as I am trying to keep this as academic as possible.


« Last Edit: November 28, 2015, 12:57:50 AM by akosi »
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akosi

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Re: Pineal gland calcification and the role of fluoride on pineal physiology
« Reply #1 on: November 27, 2015, 10:44:40 PM »

This makes the solution obvious, yes?  Poison goes in, so all we need to do is stop consumption of fluoridated products and flush the poison out, right?  Unfortunately not.  As mentioned earlier the fluoride from water displaces HO from hydroxyapatite, forming fluorapatite.  Because of the way the halogen family is arranged, once this bond is created, it is extremely difficult to break.  This is why fluoride is a good idea when it comes to teeth, and why it is such a bad idea when it comes to mandatory medication through the water supply.  I won't post them here, but many pictures can be found from the damages of excess fluoride consumption.  In many of these cases the individual is paralyzed, either partially or seriously.

So, the real solution is multifold.  First, one should seek to remove as much of the offending factor as possible.  In this case, this means water filtration systems installed to remove fluoride from the tap, fluoride free toothpaste used instead of fluoridated (toms and burt's bees make these).  Second, one should seek to chelate, detox, and bind the fluoride to help migrate it out of the body.  This is extremely difficult however due to the structural configuration of fluorapatite, and is actually believed by the mainstream to be impossible, at least with other halogens.  Fortunately, there are experiments which show us otherwise.


Iodine supplementation markedly increases urinary excretion of fluoride and bromide

Quote
Therefore, increasing iodide intake should lower bromide levels in the thyroid, preventing and reversing its thyrotoxic and goitrogenic effects. The same applies to fluoride. Galletti and Joyet (12) evaluated the effect of 5-10 mg fluoride on thyroid functions in hyperthyroid patients. Although fluoride inhibited the iodide-concentrating mechanism of the thyroid, fluoride did not accumulatein the thyroid. Based on their radioactive tracer studies, they concluded "Fluorine does not impair the capacity of the gland to synthesize thyroid hormones when there is an abundance of iodide in the blood." Therefore, fluoride toxicity depends on iodide supply.

Quote
The baseline level of urinary fluoride was very low, but bromide concentration was 18.4 mg/24h, 3 times the ADI recommended by Van Leeuwen et al. (6) Following supplementation with the iodine/iodide preparation, there was aprogressive increase in the excretion of fluoride and bromide. With 3 tablets, the 24h excretion of fluoride was 17.5 times baseline level; and for bromide, 18 times baseline level. These high levels persisted even after one month of supplementation at 3 tablets/day, being 15 times baseline level for fluoride, and 16 times for bromide. After one month, the estimated total amount of halide excreted was 24 mg fluoride and 8700mg bromide. It is unlikely that such large amounts of halides came from the thyroid gland. It would seem that the whole body is being detoxified. Orthoiodo-supplementation could be used under medical supervision to detoxify the body from unwanted halides in a manner similar to the use of EDTA for the detoxification of heavy metals.

Iodine is one tool in our arsenal, and can come from a number of sources, even Lugol's solution which can be found at most all drugstores.  The ideal form of iodine however comes from Atlantic sourced Kelp, Dulse, and other seaweeds.  These sea vegetables serve as mineral bio-accumulators, amassing huge amounts of iodine among other rare trace minerals.  One can literally feel the nutrients when consuming these seaweeds.  Daily consumption will serve to slowly displace fluoride, putting iodine in its place.  Iodine, being a halogen like fluoride, both compete for the same spots in the body.  Fluoride is much much much stronger and harder to break apart once bound, however it is not invincible by any means.

Scouring the literature, one can find that fluorapatite is also sensitive to acid degradation.  When it comes to hydroxyapatite, a ph of 4.5-5.5 is enough to cause the creation of fluorapatite when in the presence of fluoride.  When fluorapatite is present however, the ph must drop below 4.5 for the displacement to occur.  If fluoride is present during this displacement, fluoridated hydroxyapatite is formed instead, which is even harder to wear down than its parent compound, fluorapatite.  A steady consumption of iodine containg sea vegetables will both prevent the fluoroapatite from becoming fluoridated hydroxyapatite during this process, and will also expedite the removal of fluoride from the body.  Because the pineal gland is surrounded by blood however, there will most likely be a much less significant degree of detoxification of fluoride than if in an acidic medium.  To no surprise, many acidic foods are claimed to help decalcify the pineal gland.  The various acids found in fruit (malic, citric, absorbic, formic, boric etc) may serve as vital co-factors with iodine in order to break the bond.

Aside from here is one other known method to help assist decalcifying the pineal gland, and this is through the use of minerals.  Boron, calcium and magnesium are the main ones, and zinc wouldn't hurt either but probably isn't necessary.

Effect of boron on urinary and faecal excretion of minerals in buffalo calves fed high fluoride ration

Quote
order to assess the ameliorative effect of boron (B) in the buffalo calves fed high fluoride (F) diet, 12 male Murrah buffalo calves of 6–8 month old were divided into three groups. Fluoride was added in the ration (as sodium fluoride, NaF) to make 60 ppm F on DM basis in group II and III were compared to group I (control). Boron was added in the ration (as borax, Na2B4O7.10H2O) to make 140 ppm B on DM basis in group III. After 90 days of experimental feeding, a metabolism trail of 7 days duration was conducted. Urine and faecal samples were collected and analysed for fluorine (F), calcium (Ca), phosphorus (P), iron (Fe), zinc (Zn) and copper (Cu). The level of F (@60 ppm) as well as B in ration did not cause a significant change in P, Zn, Cu and Fe excretion in urine and faeces. However, urinary F (42.29±2.62 ppm) and Ca (0.56±0.01) g/head/day excretion was significantly (P<0.05) higher in group II due to F addition. Further, faecal F excretion was significantly (P<0.05) higher (91.52±4.60 ppm) in group III compared to other groups due to F and B in group III. Results indicated that boron has ameliorative effect on high F intake as it induced removal of F through faeces.


A little more info on the mechanisms at play, note this is not from a scholarly source, but taken from a presumed email exchange.

Magnesium (Mg) is responsible for the production of no fewer than 300 enzymes vital for systemic homeostasis and fluoride (F-) ions are instrumental in critical Mg deficiency. F- has a not inconsiderable affinity for Mg ions, and bonds with Mg to form MgF+ and MgF2, both of which prevent the proper absorption of Mg through intestinal cell walls. Diets deficient in Mg create an opportunistic environment for F- accumulation.

Dietary and supplemental boron has been shown to 1.) elevate concentrations of assimilable Mg 2.) increase urinary fluoride excretion and 3.) via chelation, prevent the complexing of F- with Mg (the F- ions are the ligands which form metal complexes [coordination complexes] with boron). Specifically, dietary and supplemental boron (as amino acid chelate) in the stomach, prevents the complexing of Mg and other trace metals and elements with electronegative sodium fluoride (NaF), by forming coordination complexes with F- ions, rendering NaF chemically inert. F-, consequently, also is unable to complex with aluminum to form AlFx.

Summary: Sodium Fluoride (NaF) complexing agents/chelating agents, referred to herein as “ligands,” react with boron metalloid ions to form a chelate (complex ion/metal coordination complex) →

Boron ions in a hydrochloric acid (HCl)/potassium chloride (KCl)/sodium chloride (NaCl) solution (gastric acid) with a pH of 1.5 to 3.5 are solvated and a number of solvent molecules are bound to the boron ions. It is with these solvent molecules that NaF reacts, forming metal complexes or metal coordination compounds →

The NaF molecules which displace the solvent molecules are called ligands. The ligands, arranged symmetrically about a central atom (octahedron), serve as electron-donating entities, which when bonded with boron ions, form insoluble complexes.

Beets are high in Boron, while raw Cacao is high in Magnesium and Calcium.  Kelp/Dulse are high in Iodine.  Tap water and toothpaste are high in fluoride.

Any questions?
« Last Edit: November 28, 2015, 12:39:06 AM by akosi »
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plantmind

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Re: Pineal gland calcification and the role of fluoride on pineal physiology
« Reply #2 on: December 02, 2015, 04:45:35 PM »

Great write-up, very informative
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QabasOrganica.com

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Re: Pineal gland calcification and the role of fluoride on pineal physiology
« Reply #3 on: January 26, 2016, 03:44:11 PM »

Extremely good information. It's been awhile since I studied fluoride's effects. So this was a great refresher. Loved to be able to see a calcified pineal gland too. Great post.
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